Why Is Sickle Cell Disease More Common In Africa

It is the most prevalent genetic disease in the WHO African Region. They dont last as long as normal round red blood cells.

Understanding Who Suffers From Sickle Cell Anemia

Seven thousand three hundred years ago the mutation of a single gene for hemoglobin a component of blood arose among the people living in the Mediterranean region and in Africa in areas where malaria existed.

Why is sickle cell disease more common in africa. Race is important because although any race can carry the sickle cell trait this condition is most common in African Americans. Natural selection is a phenomenon in nature in which only the organisms or individuals who are best adapted to their environment tend to surv. In teaching visualizing the complex relationship between two different diseases might be hard to do on paper.

The glucose 6-phosphate dehydrogenase G6PD genotype was determined in 100 male patients with homozygous sickle cell anemia SS by a combination of quantitative assay cytochemical testing and starch-gel. A person with a single abnormal copy does not usually have symptoms and is said to have sickle cell. Over 300000 babies with sickle cell disease SCD are born annually the majority in sub-Saharan Africa.

The worlds SCD population is concentrated in three countries. Sickle cell disease SCD is an autosomal recessive disorder characterized by chronic haemolytic anaemia and painful vaso-occlusive crises. Africas most prevalent invisible condition.

This explains why the gene for sickle cell anemia is found in about 7 of the population in malaria-stricken regions but is virtually nonexistent elsewhere. An urgent need for longitudinal cohort studies. Glucose 6-phosphate dehydrogenase deficiency and sickle cell anemia.

Affected blood is less able to carry oxygen and flow smoothly which causes a host of health problems and a shorter lifespan. The cells are shaped like a crescent or sickle. In many countries 1040 of the population carries the sickle-cell gene resulting.

MedlinePlus defines sickle cell anemia as a disease in which your body produces abnormally shaped red blood cells. It is caused by a point transformation in the B-hemoglobin gene. Sickle-cell Disease SCD is an inherited disorder of haemoglobin.

Frequency and features of the association in an African community. With a model and. Several subtypes exist depending on the exact mutation in each haemoglobin gene.

People whose ancestors are from other regions where. Chromosomes come in pairs so an individual can have zero one or two genes for sickle cell. Nigeria India and the Democratic Republic of Congo figure 1 where the disease affects up to 2 percent of the population and the carrier prevalence rate sickle cell trait is as high as 10 to.

Genetics is important for this disease because sickle cell anemia is a genetic disorder caused by a mutation in the b globin gene. The answer to your question lies in the Darwins theory of evolution by the process of Natural selection. One of these diseases is sickle cell anemia and this trait can be found in about 1 in 13 African American births.

Some diseases are more common in one race than another due to genetics. Individuals with the mutated gene were more likely to survive malaria an adaptation that helped to preserve the human species. Sickle cell disease is a genetic condition that runs in families and is more common in certain races especially Black people.

SCD is common in sub-Saharan Africa with a birth prevalence that in some areas reaches 2 1 and where it is therefore a true issue of public health importance. Sickle cell disease is caused by a single point mutation Glu6Val that promotes polymerisation of haemoglobin S and sickling of erythrocytes. An attack can be set off by temperature changes stress dehydration and high altitude.

Sickle cell disease occurs when a person inherits two abnormal copies of the β-globin gene that makes haemoglobin one from each parent. Therefore SCD and SCT are more common in people whose ancestors lived in the continent. The sickle-cell gene has become common in Africa because the sickle-cell trait confers some resistance to falciparum malaria during a critical period of early childhood favouring survival of the host and subsequent transmission of the abnormal haemoglobin gene.

I learned that NHLBI has led an extensive research program on sickle-cell disease SCD since 1972 and has committed more than 1 billion to improving the understanding of the disease and identifying new methods of treatment management and prevention. Sickle cell disease one of the worlds most common genetic disorders occurs when a child inherits a trait from each parent that causes most of their red blood cells to form into crescents rather than discs. Sickle cell disease is an inherited blood disorder which causes red blood cells to change from a.

Sickle cell disease. In the same virtual lab a model that explains this relationship is included. This gene occurs in chromosome 11.

Inflammation haemolysis microvascular obstruction and organ damage characterise the clinical expression of the disease. The condition is common in large regions of Africa. Understanding sickle cell disease is actually quite interesting and leads to unexpected insights.

Sickle cell disease in Africa.

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